DIAGNOSTIC ACCURACY OF COLOR DOPPLER ULTRASOUND FOR DIAGNOSIS OF ACUTE RENAL TRANSPLANT REJECTION BY TAKING HISTOPATHOLOGY AS GOLD STANDARD IN PATIENTS PRESENTING AT TERTIARY CARE HOSPITAL, KARACHI.

J Peop Univ Med Health Sci. 2025:15(2), 133-139. http://doi.org/10.46536/jpumhs/2025/15.02.633

Abstract

OBJECTIVE: To assess how effective color Doppler ultrasound (CDUS) is in diagnosing acute renal transplant rejection (RTR) compared to using histopathology as the standard in patients showing signs of acute rejection following renal transplant at a specialized hospital in Karachi. METHODS: This A detailed cross-sectional research was carried out at the Radiology Department of SIUT in Karachi., from February 2019 till August 2019. All the patients of either gender aged 18 years and above who have undergone renal transplantation and are presenting with clinical suspicion of acute renal transplant rejection were included. All patients those patients underwent Color Doppler Ultrasound evaluation of the transplanted kidney followed by histopathological examination through renal transplant biopsy. Findings were cross-tabulated To evaluate the sensitivity, specificity, positive and negative predictive values, and diagnostic precision. RESULTS: Mean age of the patients The average age of the participants was 51.12±7.57 years. Out of the total, 18 individuals (60%) were males and 12 individuals (40%) were females. Additionally, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of CDUS in detecting acute rejection of renal transplants, with histopathology as the reference standard, were determined to be 92%, 80%, 95.8%, 66.7%, and 90%, respectively. CONCLUSION: CDUS observed to be an accurate, reliable, and non-invasive diagnostic tool for acute renal transplant rejection, helping to avoid unnecessary surgeries and enabling early, effective management, particularly in resource-poor settings.