THE ROLE OF GINGER ON BODY WEIGHT AND MORPHOLOGICAL CHANGES IN SMALL INTESTINE OF WISTAR ALBINO RATS.

Abstract

Introduction: Obesity is one of the big health issues globally1. Millions of individuals suffered from obesity and having the risk of developing Hypertension, cardiovascular dysfunction, Diabetes mellitus, and metabolic disorders. Objectives: To determine and compared the role of ginger on body weight and morphological changes in small intestine of normal and obese Wistar albino rats. Methodology: This animal study was conducted at the Department of Anatomy PUMHS with the collaboration of AHVS-SAU Tando Jam, for 6 months from January 2018 to June 2018. Sixty (60) healthy male adult Wistar Albino rats (WARs) with body weight (BW) of 180.0 – 220.0 gm were selected. Rats were taken from the Animal Resource Center of SAU Tando Jam. The WARs were divided into 3-groups with 20 rats in each group. Control group WARs were fed a normal diet, Group B HF-diet provoked group and Group C Ginger treated group of rich fatty diet After when, the experimental study was about to end, the animals were sacrificed and pieces of the small intestine were fixed in 10.0% formalin for 24 hours, and embedded in paraffin. Findings of all group animals were recorded. A pre-designed proforma was used for the collection and documentation of data during research. SPSS 22.0 was used to analyze data. Results: In this study, no significant difference was found in initial BW among all groups (p<0.163) was quite insignificant. Final BW was significantly raised in group B of a fatty diet, and in ginger used group it was reduced almost equal to controls (p<0.05). The mean value of intestinal weight and intestinal diameter was significantly greater only in fatty diet group B as compared to normal diet group whereas intestinal diameter among groups was insignificant with (p<0.058). Conclusion: The present study concluded that ginger consumption had a significant impact on the reduction of body weight in obese WARs as compare to normal healthy WARs.